Randomized, double-blind, placebo-controlled clinical trial studying the effects of Turmeric in combination with mefenamic acid in patients with primary dysmenorrhoea.

Sepideh Hesami, Maria Kavianpour, Mohamadreza Rashidi Nooshabadi, Mojgan Yousefi, Fatemeh Lalooha, Hossein Khadem Haghighian

Journal: Journal of gynecology obstetrics and human reproduction 2021;50(4):101840

PMID: 32585392

Full Text on Elsevier Science View on PubMed

Abstract

Primary dysmenorrhea (PDM) is one of the common complaints in women. This study aimed to assess the effects of turmeric and mefenamic acid and a combination compared with placebo on PDM. This clinical trial was conducted on dormitory students with PDM. Subjects completed the visual analog scale (VAS) before randomization. One hundred twenty-eight patients, randomly assigned to one of following groups: Turmeric group (n=32), mefenamic acid group (n=32), turmeric and mefenamic acid group (n=32), and placebo group (n=32). Turmeric and mefenamic acid were administrated in 500mg and 250mg, respectively. Pain severity was assessed in the baseline and the end line by VAS. Statistical analysis was performed using SPSS software. The combination of turmeric and mefenamic acid, dramatically, alleviated pain in comparison to other groups. Our results illustrated that combination of turmeric and mefenamic acid would be better in pain alleviation in PDM.

Address: Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran; Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.; Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Dept. of Obstetrics and Gynecology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.; Student Research Committee, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran; Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: [email protected].

DOI: 10.1016/j.jogoh.2020.101840

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MeSH Terms: Anti-Inflammatory Agents, Non-Steroidal, Curcuma, Curcumin, Double-Blind Method, Drug Therapy, Combination, Dysmenorrhea, Female, Humans, Mefenamic Acid, Phytotherapy, Placebos, Students, Young Adult