Occlusion vs. skin barrier function.

Hongbo Zhai, Howard I Maibach

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2002;8(1):1-6

PMID: 12005114

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Abstract

BACKGROUND/AIMS

Skin occlusion may increase percutaneous absorption of applied chemicals, with some exceptions. It also obstructs the normal ventilation of the skin surface and increases stratum corneum hydration and hence compromises skin barrier function.

METHODS/RESULTS

This review focuses the effects of occlusion on skin barrier function, in particularly, as defined with objective skin bioengineering technology.

CONCLUSIONS

The effects of occlusion on skin barrier function have been defined with various techniques. Optimal hydrocolloid materials can absorb excess water and reduce the unfavourable effects of occlusion.

Address: Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.

DOI: 10.1046/j.0909-752x.2001.10311.x

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MeSH Terms: Administration, Cutaneous, Bandages, Colloids, Dermatitis, Irritant, Humans, Pharmacokinetics, Skin