Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome.

Galia V Anguelova, Monique H M Vlak, Arthur G Y Kurvers, Roselyne M Rijsman

Journal: Sleep medicine clinics 2020;15(2):277-288

PMID: 32386701

Full Text on Elsevier Science View on PubMed

Abstract

This article provides an updated practical guide for the treatment of primary restless legs syndrome (RLS). Articles that appeared after the American Academy of Neurology guideline search were reviewed according to the same evidence rating schedule. We found limited evidence for nonpharmacologic treatment options. In moderate to severe primary RLS, pharmacologic options may be considered, including iron suppletion, an α2δ ligand, a dopamine agonist, a combination of an α2δ ligand and a dopamine agonist, or oxycodone/naloxone. This article includes treatment options in case of augmentation.

Address: Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, The Netherlands.; Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, The Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.jsmc.2020.02.013

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MeSH Terms: Dopamine Agonists, Humans, Restless Legs Syndrome