In vitro Inhibition of HHV-6 replication by sophocarpines.

Hamida B Qavi, Philip R Wyde, Mushtaq A Khan

Journal: Phytotherapy research : PTR 2002;16(2):154-6

PMID: 11933118

Abstract

The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV-6 Z29 strain and Molt-3 cells. The cytotoxic (IC(50)) and the antiviral (ED(50)) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV-6 replication.

Address: Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia.

DOI: 10.1002/ptr.949

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MeSH Terms: Alkaloids, Antiviral Agents, Cell Survival, Dose-Response Relationship, Drug, Ganciclovir, Herpesvirus 6, Human, Humans, Inhibitory Concentration 50, Plant Extracts, Sophora, Tumor Cells, Cultured, Virus Replication