Halogenases: structures and functions.

Hannes Ludewig, Samuel Molyneux, Scarlet Ferrinho, Kai Guo, Rosemary Lynch, Danai S Gkotsi, Rebecca Jm Goss

Journal: Current opinion in structural biology 2021;65():51-60

PMID: 32619660

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Abstract

Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.

Address: School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK. Electronic address: [email protected].

DOI: 10.1016/j.sbi.2020.05.012

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MeSH Terms: Chloride Peroxidase, Halogenation, Substrate Specificity