The increased amount of coffee consumption lowers the incidence of fatty liver disease in Korean men.

Hye-Kyung Chung, Ji Sun Nam, Mi-Yeon Lee, Yong-Bum Kim, Yu-Sam Won, Won-Jun Song, Young-Hwan Kim, Chul Woo Ahn, Ki-Chul Sung

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 2020;30(10):1653-1661

PMID: 32631703

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND AND AIMS

Coffee is known to have a beneficial effect on various liver diseases. The aim of this retrospective longitudinal study was to investigate an association between the amount of coffee consumption and the incidence of fatty liver disease in Korean adults.

METHODS AND RESULTS

Data from a total of 91,436 male and female subjects with the mean follow-up period of 2.8 years were analyzed. The incidence of fatty liver was not associated with the amount of coffee consumption at baseline, but it was associated with the change in the amount of coffee consumption at the follow-up period. Multiple linear regression analyses showed that hazard ratios for incidence of fatty liver disease were significantly low in "increase" group comparing with "no change" group in fully adjusted model. When a subgroup analysis by gender was conducted, similar significant results were observed in male subjects, but not in females.

CONCLUSIONS

The increment in the amount of coffee consumption is associated with the lower incidence of fatty liver in Korean men and suggests that increasing the coffee consumption may have a protective effect on fatty liver.

Address: Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.; Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.numecd.2020.05.026

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MeSH Terms: Adult, Coffee, Fatty Liver, Female, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Protective Factors, Retrospective Studies, Risk Factors, Seoul, Sex Factors