Metabolic cell communication within tumour microenvironment: models, methods and perspectives.

M Parri, L Ippolito, P Cirri, M Ramazzotti, P Chiarugi

Journal: Current opinion in biotechnology 2020;63():210-219

PMID: 32416546

Full Text on Elsevier Science View on PubMed

Abstract

Environmental cues are essential in defining tumour malignancy, by promoting tumour initiation, progression and metastatic spreading. Stromal cells may metabolically cooperate or compete with cancer cells, playing a mandatory role in defining cancer metabolic plasticity, potentially dictating the final tumour outcome. Assessing shared nutrients between different tumoural or stromal compartments is essential to understand the impact of environmental nutrients on the metabolic plasticity of tumours. Here, we review analytical and computational approaches for studying the tumour metabolic microenvironment, the destiny of nutrients shared among tumour and stromal populations, as well as the molecular modules of these metabolic relationships.

Address: Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2020.03.001

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MeSH Terms: Cell Communication, Disease Progression, Humans, Neoplasms, Stromal Cells, Tumor Microenvironment