Skin characteristics associated with foot callus in people with diabetes: A cross-sectional study focused on desmocollin1 in corneocytes.

Kahori Tsuruoka, Makoto Oe, Takeo Minematsu, Sanai Tomida, Yumiko Ohashi, Yuko Shimojima, Yukie Mori, Shiori Nitta, Qi Qin, Masatoshi Abe, Toshimasa Yamauchi, Hiromi Sanada

Journal: Journal of tissue viability 2021;29(4):291-296

PMID: 32653294

Full Text on Elsevier Science View on PubMed

Abstract

AIM

The purpose of this study was to investigate the degradation of desmocollin-1 (DSC1), a member of the desmosomal cadherin family in patients with diabetes, as well as the factors associated with the suppression of DSC1 degradation.

METHODS

This cross-sectional study included 60 cases of foot callus involving 30 patients with diabetes (DM) and 30 matched volunteers without diabetes (non-DM). DSC1 degradation in samples from debrided calluses was analysed using western blotting. Skin hydration, a factor reported to suppress DSC1 degradation, was measured using a mobile moisture device.

RESULTS

Full-length DSC1 (approximately 100 kDa) was detected in six participants only in the DM group, and no relationship was found between the suppression of DSC1 degradation and decreased skin hydration in the DM group. There was no significant difference in skin hydration values between the DM and non-DM groups.

CONCLUSION

DSC1 degradation was suppressed in the DM group. There was no relationship between the suppression of DSC1 degradation and decreased skin hydration in the DM group. Current external force callus care would not be sufficient. This study highlights the need to develop novel callus care to enhance the degradation of DSC1.

Address: Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Nursing Department, The University of Tokyo Hospital, Tokyo, Japan.; Sapporo Dermatology Clinic, Sapporo, Japan.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: [email protected].

DOI: 10.1016/j.jtv.2020.05.003

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MeSH Terms: Aged, Aged, 80 and over, Ankle Brachial Index, Blotting, Western, Body Mass Index, Bony Callus, Cross-Sectional Studies, Desmocollins, Diabetes Complications, Female, Foot, Humans, Male, Middle Aged, Skin, Statistics, Nonparametric