Impact of environmental factors and physical activity on disability and quality of life in CIDP.

Antonio Toscano, Marinella Carpo, Luana Benedetti, Angelo Schenone, Giuseppe Liberatore, Erdita Peci, Emanuele Spina, Stefano Tronci, Stefano Cotti Piccinelli, Guido Cavaletti, Luca Gentile, Laura Piccolo, Luca Leonardi, Giorgia Mataluni, Marta Ruiz, Mario Sabatelli, Lucio Santoro, Eduardo Nobile-Orazio, Andrea Cortese, Elisa Bianchi, Dario Cocito, Fiore Manganelli, Raffaella Fazio, Massimiliano Filosto, Ettore Beghi, Anna Mazzeo, Giuseppe Cosentino, Pietro Emiliano Doneddu, Stefano Jann, Angelo Maurizio Clerici, Giovanni Antonini, Gabriele Siciliano, Girolama Alessandra Marfia, Chiara Briani, Giuseppe Lauria, Tiziana Rosso

Journal: Journal of neurology 2021;267(9):2683-2691

PMID: 32430573

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Abstract

A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, we collected data on lifestyle and dietary habits of the patients included in the Italian CIDP database to investigate the possible influence of modifiable lifestyle factors on disability and QoL. Questionnaire data were available for 323 patients. The effect of lifestyle and dietary exposures on impairment, disability and QoL was evaluated using logistic regression models, adjusting for age, sex, disease duration, physical activity and smoking. Physical activity was associated with lower sensory impairment by the ISS scale, less disability by the INCAT and RODS scale and a better QoL in all the domains of EURO-QoL scale with the exception of anxiety/depression. None of the other parameters had an impact on these scales. This study adds evidence to the possible role of physical activity in improving symptom severity, disability and QoL in patients with CIDP. None of the other environmental factors investigated appeared to have an impact on the severity and health perception of CIDP.

Address: Neuromuscular and Neuroimmunology Service, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.; Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.; Istituti Clinici Scientifici Maugeri, Turin, Italy.; Department of Neuroscience, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', Naples, Italy.; Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy.; Center for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST 'Spedali Civili', University of Brescia, Brescia, Italy.; Department of Clinical and Experimental Medicine, Unit of Neurology, University of Messina, Messina, Italy.; University of Pavia, Pavia, Italy.; IRCCS Mondino Foundation, Pavia, Italy.; Department of Neuroscience, Niguarda Ca' Granda Hospital, Milan, Italy.; Neurology Unit, Circolo and Macchi Foundation Hospital, DBSV, Insubria University, Varese, Italy.; Department of Neurology Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Unit of Neuromuscular Diseases, 'Sapienza' University of Rome, Sant'Andrea Hospital, Rome, Italy.; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.; Department of Systems Medicine, Dysimmune Neuropathies Unit, Tor Vergata University of Rome, Rome, Italy.; Department of Neuroscience, Neurology Unit, University of Padua, Padua, Italy.; Unit of Neuroalgology, IRCCS Foundation 'Carlo Besta' Neurological Institute, Milan, Italy.; Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, Milan, Italy.; ULSS2 Marca Trevigiana, UOC Neurologia-Castelfranco Veneto, Treviso, Italy.; School of Medicine and Surgery and Experimental Neurology Unit, University of Milano-Bicocca, Monza, Italy.; ASST Bergamo Ovest-Ospedale Treviglio, Treviglio, Italy.; IRCCS Ospedale Policlinico San Martino Genova, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy.; Department of Neuroscience, University of Turin, Turin, Italy.; Università Cattolica del Sacro Cuore. Sede di Roma, Rome, Italy.; Centro Clinico NEMO Adulti, Rome, Italy.; Neuromuscular and Neuroimmunology Service, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy. [email protected].; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Milan University, Milan, Italy. [email protected].

DOI: 10.1007/s00415-020-09916-y

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MeSH Terms: Persons with Disabilities, Exercise, Humans, Italy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Quality of Life