Structure-Activity Relationships of Butyrophilin 3 Ligands.

Andrew J Wiemer

Journal: ChemMedChem 2021;15(12):1030-1039

PMID: 32453919

Free Full Text on PubMed Central View on PubMed

Abstract

Phosphoantigens (pAgs) are small phosphorus-containing molecules that stimulate Vγ9Vδ2 T cells with sub-nanomolar cellular potency. Recent work has revealed that these compounds work through binding to the transmembrane immunoglobulin butyrophilin 3A1 (BTN3A1) within its intracellular B30.2 domain. Engagement of BTN3A1 is critical to the formation of an immune synapse between cells that contain pAgs and the Vγ9Vδ2 T cells. This minireview summarizes the structure-activity relationships of pAgs and their implications to the mechanisms of butyrophilin 3 activation leading to Vγ9Vδ2 T cell response.

Address: Department of Pharmaceutical Sciences and Institute for Systems Genomics, University of Connecticut, 69N. Eagleville Road, Storrs, CT, 06269, USA.

DOI: 10.1002/cmdc.202000198

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

https://doi.org/10.1002/cmdc.202000198

MeSH Terms: Antigens, CD, Binding Sites, Butyrophilins, Humans, Intraepithelial Lymphocytes, Ligands, Molecular Structure, Organophosphates, Protein Binding, Protein Domains, Structure-Activity Relationship