De Novo Design of Cell-Penetrating Foldamers.

Hidetomo Yokoo, Takashi Misawa, Yosuke Demizu

Journal: Chemical record (New York, N.Y.) 2021;20(9):912-921

PMID: 32463155

Abstract

Cell-penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell-membrane permeability. Based on this knowledge, a variety of cell-penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell-penetrating foldamers containing various building blocks, and their application as DDS carriers.

Address: Division of Organic Chemistry, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Yokohama, Kanagawa, 230-0045, Japan.

DOI: 10.1002/tcr.202000047

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https://doi.org/10.1002/tcr.202000047

MeSH Terms: Amino Acids, Cell-Penetrating Peptides, Drug Carriers, Humans, Peptides, Cyclic, Peptoids, Proline, Urea