Cyclosporine Anionic and Cationic Ophthalmic Emulsions in Dry Eye Disease: A Literature Review.

Louis Tong, Chi Chin Sun, Kyung Chul Yoon, Ruben Lim Bon Siong, Vilavun Puangsricharern, Christophe Baudouin

Journal: Ocular immunology and inflammation 2022;29(7-8):1606-1615

PMID: 32469256

Abstract

: There are no clinical studies directly comparing anionic and cationic emulsions of cyclosporine for the treatment of dry eye disease (DED). We therefore conducted a literature review to evaluate the efficacy and safety of these different formulations.: A literature search was performed in Embase and Medline from January 1999 to May 2019 to identify publications that evaluated clinical outcomes with either cyclosporine anionic or cationic emulsion in patients with moderate-to-severe or severe DED.: Thirteen publications met criteria. In patients with moderate-to-severe disease, evidence demonstrated improvement in the signs of DED with both formulations. However, improvement in symptoms was not consistently demonstrated. Studies specifically in severe DED were only identified with the cationic emulsion and showed improvement in the objective signs of DED. There were no obvious differences in tolerability between products.: Both formulations are effective for the treatment of moderate-to-severe DED and are well tolerated.

Address: Corneal and External Eye Disease Service, Singapore National Eye Center, Singapore, Singapore.; Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore.; Eye-Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, Eye-Academic Clinical Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.; Department of Ophthalmology and Visual Sciences, College of Medicine, University of the Philippines, Manila, Philippines.; Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Center of Excellence for Cornea and Stem Cell Transplantation, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; IHU FOReSIGHT, INSERM-DGOS CIC, CHNO Des Quinze-Vingts, Paris, France.; Institut de la Vision, Sorbonne Universités, INSERM, CNRS, Paris, France.

DOI: 10.1080/09273948.2020.1757121

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MeSH Terms: Anions, Cations, Cyclosporine, Dry Eye Syndromes, Emulsions, Humans, Immunosuppressive Agents