Identification of type 2 diabetes loci in 433,540 East Asian individuals.

Address: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.; The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.; Biomedical Science, Hallym University, Chuncheon, South Korea.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.; Stanford University, Stanford, CA, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.; Genentech, South San Francisco, CA, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; School of Biological Sciences, University of Manchester, Manchester, UK.; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Chinese Academy of Medical Sciences, Beijing, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Division of Endocrinology & Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.; Department of Biostatistics, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.; Department of Ophthalmology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.; Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.; Department of Regional Resource Management, Ehime University Faculty of Collaborative Regional Innovation, Ehime, Japan.; Severance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines.; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan.; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.; Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau, China.; Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.; Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Kurume University School of Medicine, Kurume, Japan.; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [email protected].; Nuffield Department of Population Health, University of Oxford, Oxford, UK. [email protected].; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK. [email protected].; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea. [email protected].; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [email protected].; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. [email protected].