P2X receptors and trigeminal neuralgia.

Jia-Juan Li, Zeng-Xu Liu, Ya-Ling Zhang, Guo-Yong Xue

Journal: Neuroreport 2020;30(10):725-729

PMID: 31095112

Abstract

There is currently no effective cure for trigeminal neuralgia (TN) - a relatively common disease that causes long-term pain in patients. Previous research has shown that ionotropic ATP signaling through excitatory and calcium-permeable P2X receptor channels plays a critical role in pathological pain generation and maintenance. In this paper, we review several hypotheses on the pathogenic mechanisms underlying TN. We further discuss pathways or agents that can target P2X expression in TN, thereby affecting pain induction and maintenance.

Address: The Second Clinical Medical College of Nanchang University.; Department of Anatomy, Medical School of Nanchang University, Nanchang, People's Republic of China.

DOI: 10.1097/WNR.0000000000001266

Link outs

Free resources

Medical:

https://medlineplus.gov/trigeminalneuralgia.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Adenosine Triphosphate, Humans, Pain, Purinergic P2X Receptor Antagonists, Receptors, Purinergic P2X, Trigeminal Ganglion, Trigeminal Neuralgia