Molecular Recognition of Zwitterions with Artificial Receptors.

Ignacio Alfonso, Jordi Solà

Journal: Chemistry, an Asian journal 2020;15(7):986-994

PMID: 32017445

Abstract

Many biomolecules exist as internal ion pairs or zwitterions within a biologically relevant pH range. Despite their importance, the molecular recognition of this type of systems is specially challenging due to their strong solvation in aqueous media, and their trend to form folded or self-assembled structures by pairing of charges of different sign. In this Minireview, we will discuss the molecular recognition of zwitterions using non-natural, synthetic receptors. This contribution does not intend to make a full in-depth revision of the existing research in the field, but a personal overview with selected representative examples from the recent literature.

Address: Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia Jordi, Girona 18-26, 08034, Barcelona, Spain.

DOI: 10.1002/asia.201901789

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MeSH Terms: Drug Delivery Systems, Hydrogen Bonding, Hydrogen-Ion Concentration, Ions, Molecular Conformation, Receptors, Artificial, Solubility