Spontaneous Sexual Development and Heavy Menstrual Bleeding in 45,X Monosomy and 45,X/47,XXX Mosaic Turner Syndrome and a Review of the Literature.

Myeong Jin Kim, Hwal Rim Jeong

Journal: Journal of pediatric and adolescent gynecology 2020;33(5):602-606

PMID: 32315714

Full Text on Elsevier Science View on PubMed

Abstract

Turner syndrome (TS) is one of the most common sex chromosome disorders and is characterized by short stature and gonadal dysgenesis. A few patients with TS achieve normal sexual development, menarche, and even pregnancy. We encountered two cases of Turner syndrome with spontaneous sexual development and menstruation. The patients had different karyotypes, 45,X monosomy and 45,X/47,XXX mosaic TS, and presented with severe anemia due to excessive menstrual bleeding. Abnormal uterine bleeding patterns are expected in patients with primary ovarian insufficiency; however, the menstrual patterns of patients with TS have not been well described in the literature. Here, we describe these cases along with a brief review of the relevant literature.

Address: Department of Pediatrics, School of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.; Department of Pediatrics, School of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.jpag.2020.04.002

Link outs

Free resources

Medical:

https://medlineplus.gov/turnersyndrome.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Adolescent, Adult, Anemia, Iron-Deficiency, Child, Preschool, Chromosomes, Human, X, Female, Humans, Menarche, Menorrhagia, Pregnancy, Sex Chromosome Aberrations, Sex Chromosome Disorders of Sex Development, Sexual Development, Trisomy, Turner Syndrome