The next generation of liposome delivery systems: recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients.

R M Abra, R B Bankert, F Chen, N K Egilmez, K Huang, R Saville, J L Slater, M Sugano, S J Yokota

Journal: Journal of liposome research 2003;12(1-2):1-3

PMID: 12604032

Abstract

Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-beta1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

Address: ALZA Corp, Mountain View, California 94025, USA.

DOI: 10.1081/lpr-120004770

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

https://www.tandfonline.com/doi/10.1081/lpr-120004...

MeSH Terms: Ammonium Sulfate, Anticoagulants, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Camptothecin, Cisplatin, Dextrans, Doxorubicin, Drug Delivery Systems, Ligands, Lipid Bilayers, Liposomes