What do you need to know about mass spectrometry? A brief guide for endocrinologists.

Jean-Benoît Corcuff, Dominique Ducint, Julie Brossaud

Journal: Annales d'endocrinologie 2020;81(2-3):118-123

PMID: 32340850

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Abstract

In routine hormonology, liquid chromatography mass spectrometry (LCMS) is now an established technique for androgen, urinary cortisol and metanephrine assay. It has the undeniable advantage of great analytical specificity, but with sensitivity that clearly depends on financial investment in a very high-end spectrometer. We describe the general principles of LCMS and the routine applications so far developed in hormonology. The purpose is to familiarise endocrinologists with the techniques under development and their pros and cons.

Address: Laboratoire d'hormonologie, hôpital Haut-Lévêque, CHU de Bordeaux, 33604 Pessac, France; Nutrition et neurobiologie intégrée, UMR 1286, université de Bordeaux, 33076 Bordeaux, France; Groupe de biologie spécialisée, societé française de medecine nucléaire, 5, rue Ponscarme 75013, Paris, France. Electronic address: [email protected].; Plateau technique de mesures physiques, hôpital Pellegrin, CHU de Bordeaux, 33600 Bordeaux, France. Electronic address: [email protected].; Laboratoire d'hormonologie, hôpital Haut-Lévêque, CHU de Bordeaux, 33604 Pessac, France; Nutrition et neurobiologie intégrée, UMR 1286, université de Bordeaux, 33076 Bordeaux, France; Groupe de biologie spécialisée, societé française de medecine nucléaire, 5, rue Ponscarme 75013, Paris, France. Electronic address: [email protected].

DOI: 10.1016/j.ando.2020.03.021

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MeSH Terms: Androgens, Chromatography, Liquid, Diagnostic Techniques, Endocrine, Diagnostic Tests, Routine, Education, Medical, Continuing, Endocrinologists, Humans, Hydrocortisone, Mass Spectrometry, Metanephrine