Endoscopic Ultrasound-Guided Treatment of Pancreatic Cancer.

Irina M Cazacu, Ben S Singh, Adrian Saftoiu, Manoop S Bhutani

Journal: Current gastroenterology reports 2020;22(6):27

PMID: 32350629

Abstract

PURPOSE OF REVIEW

The aim of this review is to evaluate the emerging role of endoscopic ultrasound (EUS) in the guidance of tumor-targeted therapies for patients with pancreatic cancer (PC).

RECENT FINDINGS

EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described to date. EUS-guided fiducial placement for SBRT in pancreatic cancer has entered the clinical practice and is performed at many centers clinically without a research protocol. EUS-guided brachytherapy and RFA have been shown to be feasible and safe procedures, and potentially offer local disease control. Other potential techniques of EUS-guided treatment of pancreatic cancer are still considered experimental, with many of them appearing to be safe and reasonably well tolerated. However, their effectiveness and exact role in oncological treatment have yet to be established. Clinical trials with many of the techniques/agents described are underway and multicentric randomized trials with prospective design are eagerly awaited.

Address: Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.; Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania.; Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA. [email protected].

DOI: 10.1007/s11894-020-00767-1

Link outs

Free resources

Medical:

https://medlineplus.gov/pancreaticcancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-BRIP1-5

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Full Text Sources:

https://dx.doi.org/10.1007/s11894-020-00767-1

MeSH Terms: Ablation Techniques, Antineoplastic Agents, Brachytherapy, Carcinoma, Pancreatic Ductal, Endosonography, Fiducial Markers, Humans, Injections, Intralesional, Pancreatic Neoplasms, Ultrasonography, Interventional