Effect of green cardamom on lipoproteins, glycemic control and anthropometric parameters: A meta-analysis of randomized clinical trials.

Omid Asbaghi, Elham Eslampour, Željko Reiner, Bita Badehnoosh, Fariba Kolahdooz, Sajjad Moradi, Shahrzad Hashemi Dizaji, Zatollah Asemi

Journal: Clinical nutrition ESPEN 2021;37():24-33

PMID: 32359750

Full Text on Elsevier Science View on PubMed

Abstract

INTRODUCTION

The aim of this systematic review and meta-analysis was to summarize all the existing randomized controlled trials (RCTs) evidence and to evaluate the effects of green cardamom on lipoproteins, glycemic control and anthropometric parameters in healthy and/or with disease types compared with the control.

METHOD

Two independent authors systematically searched online databases including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until 30th July 2019. RCTs complying with the following criteria were included in this meta-analysis: human trials with either cross-over design or parallel design, trials with data on the effects of green cardamom on serum lipoproteins and glycemic control and anthropometric parameters with standard deviation and related 95% confidence interval for the both intervention and placebo groups. The heterogeneity among the included studies was assessed using Cochrane's Q test and I-square (I) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.

RESULT

Seven trials were included in this meta-analysis. Triglycerides were significantly reduced after cardamom supplementation when compared with the control group. Cardamom intake from 3 small studies resulted in a significant increase in BMI when compared with the control group. However, cardamom supplementation did not have any significant effect on total cholesterol, LDL-cholesterol, HDL-cholesterol, fasting plasma glucose and body weight when compared with the control group.

CONCLUSION

This meta-analysis demonstrated that green cardamom intake significantly reduced triglycerides levels which may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.

Address: Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: [email protected].; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: [email protected].; Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address: [email protected].; Department of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: [email protected].; Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada. Electronic address: [email protected].; Halal Research Centre of IRI, FDA, Tehran, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: [email protected].; Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.clnesp.2020.03.015

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MeSH Terms: Blood Glucose, Elettaria, Glycemic Control, Humans, Lipoproteins, Randomized Controlled Trials as Topic