Evolution of Lantibiotic Salivaricins: New Weapons to Fight Infectious Diseases.

Abdelahhad Barbour, Philip Wescombe, Leif Smith

Journal: Trends in microbiology 2021;28(7):578-593

PMID: 32544444

Full Text on Elsevier Science View on PubMed

Abstract

Lantibiotic salivaricins are polycyclic peptides containing lanthionine and/or β-methyllanthionine residues produced by certain strains of Streptococcus salivarius, which almost exclusively reside in the human oral cavity. The importance of these molecules stems from their antimicrobial activity towards relevant oral pathogens which has so far been applied through the development of salivaricin-producing probiotic strains. However, salivaricins may also prove to be of great value in the development of new and novel antibacterial therapies in this era of emerging antibiotic resistance. In this review, we describe the biosynthesis, antimicrobial activity, structure, and mode of action of the lantibiotic salivaricins characterized to date. Moreover, we also provide an expert opinion and suggestions for future development of this important field of microbiology.

Address: Faculty of Dentistry, University of Toronto, Toronto, ON, Canada. Electronic address: [email protected].; Yili Innovation Center Oceania, Lincoln University, Christchurch, New Zealand.; Department of Biology, College of Science, Texas A&M University, College Station, TX, USA.

DOI: 10.1016/j.tim.2020.03.001

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MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Bacterial Proteins, Bacteriocins, Humans, Microbial Sensitivity Tests, Mouth, Probiotics, Sequence Alignment, Streptococcus salivarius