Anti-microbial activity of curcumin nanoformulations: New trends and future perspectives.

Simin Sharifi, Nazanin Fathi, Mohammad Yousef Memar, Seyed Mahdi Hosseiniyan Khatibi, Rovshan Khalilov, Ramin Negahdari, Sepideh Zununi Vahed, Solmaz Maleki Dizaj

Journal: Phytotherapy research : PTR 2020;34(8):1926-1946

PMID: 32166813

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Abstract

Curcumin has been used in numerous anti-microbial research because of its low side effects and extensive traditional applications. Despite having a wide range of effects, the intrinsic physicochemical characteristics such as low bioavailability, poor water solubility, photodegradation, chemical instability, short half-life and fast metabolism of curcumin derivatives limit their pharmaceutical importance. To overcome these drawbacks and improve the therapeutic ability of curcuminoids, novel approaches have been attempted recently. Nanoparticulate drug delivery systems can increase the efficiency of curcumin in several diseases, especially infectious diseases. These innovative strategies include polymeric nanoparticles, hydrogels, nanoemulsion, nanocomposite, nanofibers, liposome, nanostructured lipid carriers (NLCs), polymeric micelles, quantum dots, polymeric blend films and nanomaterial-based combination of curcumin with other anti-bacterial agents. Integration of curcumin in these delivery systems has displayed to improve their solubility, bioavailability, transmembrane permeability, prolong plasma half-life, long-term stability, target-specific delivery and upgraded the therapeutic effects. In this review paper, a range of in vitro and in vivo studies have been critically discussed to explore the therapeutic viability and pharmaceutical significance of the nano-formulated delivery systems to elevate the anti-bacterial activities of curcumin and its derivatives.

Address: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Biophysics and Molecular Biology, Baku State University, Baku, Azerbaijan.; Institute of Radiation Problems, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan.; Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine.; Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Baku, Azerbaijan.; Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.1002/ptr.6658

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MeSH Terms: Anti-Infective Agents, Curcumin, Humans, Nanoparticles