Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait.

Jing-Jing Li, Xu Zhang, Xiang-Chun Shen, Qing-de Long, Chang-Yan Xu, Chuan-Jiao Tan, Yan Lin

Journal: Fitoterapia 2021;143():104556

PMID: 32194169

Full Text on Elsevier Science View on PubMed

Abstract

Sophora flavescens Ait (Ku-Shen in Chinese) is a popular traditional Chinese herbal medicine in China for a long history. It shows significant pharmacological activities in the treatment of dysentery, eczema, fever, jaundice, vulvar swelling, gastrointestinal hemorrhage and inflammatory disorders. Alkaloids and flavonoids have been identified as virtual components, especially isoprenoid flavanonols are a class of characteristic compounds for S. flavescens. However, few studies have focused on isoprenoid flavonoids analyses and no comprehensive review has yet been published. In the current review, we systematically summarized the isoprenoid flavonoids, a total of 55 compounds have been isolated from S. flavescens, particularly an isoprenyl and a lavandulyl group in backbone structures. Further pharmacological activities, qualitative and quantitative chemical analyses research will contribute to the development of natural isoprenoid flavonoid products in S. flavescens.

Address: The Department of Pharmacology of Materia Medica (the State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilizaiton of Natural Medicine Resources) School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guizhou, 550025, China.; The Department of Pharmacology of Materia Medica (the State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilizaiton of Natural Medicine Resources) School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guizhou, 550025, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2020.104556

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0367...

MeSH Terms: Flavonoids, Molecular Structure, Phytochemicals, Sophora, Terpenes