Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase ( Gene: The Risk of Malignant Tumors and Other Chronic Diseases.

Maria Latacz, Jadwiga Snarska, Elżbieta Kostyra, Ewa Fiedorowicz, Huub Fj Savelkoul, Roman Grzybowski, Anna Cieślińska

Journal: Nutrients 2021;12(3):801

PMID: 32197412

Abstract

Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in , the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin's lymphoma, oral lichen planus, or multiple sclerosis.

Address: Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland.; Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.; Department of General Surgery, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland.; Independent Public Healthcare Center of Ministry of Internal Affairs and Administration with the Warmia and Mazury, Center of Oncology in Olsztyn, 10-228 Olsztyn, Poland.; Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland.; Cell Biology and Immunology Group Wageningen University and Research, 6700 AH Wageningen, The Netherlands.; Clinical Department of Trauma-Orthopedic Surgery and Spine Surgery of the Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.; Clinical Department of Orthopedics, Traumatology and Spine Surgery, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland.

DOI: 10.3390/nu12030801

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MeSH Terms: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Chronic Disease, Genetic Predisposition to Disease, Humans, Neoplasms, Polymorphism, Single Nucleotide, Vitamin D