The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India.

Madhavi Rangaswamy, Kamakshi Kartik, Murali Krishna, Ghattu Krishnaveni, Keshav Kumar, Kalyanaraman Kumaran, Rebecca Kuriyan, Pratima Murthy, Dimitri P Orfanos, Meera Purushottam, Kartik Kalyanram, Sunita Simon Kupard, Lenin Singh, Roshan Singh, B N Subodh, Kandavel Thennarasu, Mireille Toledano, Mathew Varghese, Vivek Benegal, Gunter Schumann, Sylvane Desrivieres, Nilakshi Vaidya, Udita Iyengar, Eesha Sharma, Bharath Holla, Chirag K Ahuja, Gareth J Barker, Debasish Basu, Rose Dawn Bharath, Amit Chakrabarti, Yuning Zhang, Paul Elliott, Gwen Fernandes, Amritha Gourisankar, Jon Heron, Matthew Hickman, Preeti Jacob, Sanjeev Jain, Deepak Jayarajan

Journal: Molecular psychiatry 2021;25(8):1618-1630

PMID: 32203154

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Abstract

The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].

Address: Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, UK.; Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India.; Department of Child & Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.; Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.; Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education & Research, Chandigarh, India.; Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, London, King's College, London, UK.; Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India.; ICMR-Regional Occupational Health Centre, Kolkata, India.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Rishi Valley Rural Health Centre, Rishi Valley, India.; Centre for Public Health, Bristol Medical School, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, UK.; Foundation for Research and Advocacy in Mental Health, Mysuru, India.; Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysuru, India.; Department of Mental Health and Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, India.; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; Division of Nutrition, St John's Research Institute, Bengaluru, India.; NeuroSpin, CEA, Université Paris-Saclay, Paris, France.; Molecular Genetics Laboratory, National Institute of Mental Health and Neurosciences, Bengaluru, India.; Department of Psychology, CHRIST (deemed to be university), Bengaluru, India.; Department of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bengaluru, India.; Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur, India.; Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bengaluru, India.; Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India. [email protected].; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. [email protected].; Population Neuroscience and Precision Medicine (PONS), LIN-Charite Research Group Department of Psychiatry and Psychotherapy, Charite, CCM, Humboldt University, Berlin, Germany. [email protected].; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, PR China. [email protected].

DOI: 10.1038/s41380-020-0656-1

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https://doi.org/10.1038/s41380-020-0656-1

MeSH Terms: Adolescent, Behavior, Addictive, Child, China, Europe, Humans, India, Internal-External Control, Longitudinal Studies, United States, Young Adult