Effect of soluble-viscous dietary fibre on coronary heart disease risk score across 3 population health categories: data from randomized, double-blind, placebo-controlled trials.

Vladimir Vuksan, John L Sievenpiper, Elena Jovanovski, Alexandra L Jenkins, Allison Komishon, Fei Au-Yeung, Andreea Zurbau, Hoang V T Ho, Dandan Li, Lea Smircic-Duvnjak

Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021;45(7):801-804

PMID: 32213141

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Abstract

We applied the Framingham risk equation in healthy, metabolic syndrome, and diabetes populations, following treatment with viscous fibre from konjac-based blend (KBB). KBB yielded reduction in estimated risk score by 16% (1.04 ± 0.03 vs. 0.87 ± 0.04, < 0.01) in type 2 diabetes, 24% (1.08 ± 0.01 vs. 0.82 ± 0.02, < 0.01) in metabolic syndrome, and 25% (1.09 ± 0.05 vs. 0.82 ± 0.06, < 0.01) in healthy individuals. Drivers for decreased risk were improvements in blood cholesterol and systolic blood pressure. The composite coronary heart disease risk across populations was reduced 22% ( < 0.01). Viscous fibre from konjac-xanthan reduced 10-year relative coronary heart disease using Framingham Risk Score across the glycemic status spectrum.

Address: Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.; Division of Endocrinology & Metabolism, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1A6, Canada.; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.; Clinic for Diabetes, Endocrinology & Metabolic Diseases Vuk Vrhovac, University Hospital Merkur, University of Zagreb, School of Medicine, Zagreb, Croatia.

DOI: 10.1139/apnm-2019-0728

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MeSH Terms: Adult, Amorphophallus, Blood Pressure, Cholesterol, Coronary Disease, Diabetes Mellitus, Type 2, Dietary Fiber, Double-Blind Method, Female, Humans, Male, Metabolic Syndrome, Middle Aged, Plant Extracts, Polysaccharides, Bacterial, Population Health, Risk Assessment