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15O-Water PET MPI: Current Status and Future Perspectives.

Teemu Maaniitty, Juhani Knuuti, Antti Saraste

Journal: Seminars in nuclear medicine 2021;50(3):238-247

PMID: 32284110

Full Text on Elsevier Science View on PubMed

Abstract

Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Current scanner and software technology enable quantification of global and regional MBF in clinical PET myocardial perfusion imaging studies. Reduced stress MBF or MFR measured by 15O-water PET accurately detects hemodynamically significant coronary artery stenosis defined by intracoronary fractional flow reserve (FFR) measurement in patients with suspected obstructive coronary artery disease (CAD). Furthermore, MBF and MFR provide prognostic information on mortality and risk of myocardial infarction. Clinical experience in some centers indicates that clinical application of 15O-water PET in evaluation of CAD is feasible and guides management decisions on revascularization. This review discusses basic concepts of measuring MBF with 15O-water PET and reviews clinical studies on its application in evaluation of obstructive CAD.

Copyright © 2020 Elsevier Inc. All rights reserved.

Address: Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland. Electronic address: [email protected].; Turku PET Centre, University of Turku, Turku, Finland; Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland.; Turku PET Centre, University of Turku, Turku, Finland; Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
DOI: 10.1053/j.semnuclmed.2020.02.011

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MeSH Terms: Coronary Artery Disease, Humans, Oxygen Radioisotopes, Positron-Emission Tomography, Water
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