Management of stage 0 medication-related osteonecrosis of the jaw with hyperbaric oxygen therapy: a case report and review of the literature.

Lawrence J Lin, Alison R Alfonso, Frank L Ross, Ernest S Chiu, Kenneth E Fleisher

Journal: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2021;47(2):241-251

PMID: 32574441

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Abstract

The definition of medication-related osteonecrosis of the jaw (MRONJ) includes a stage 0 presentation where exposed bone, the hallmark of this condition, is absent. Numerous management strategies have been recommended for MRONJ including hyperbaric oxygen (HBO2) therapy. This report describes a 64-year-old woman with stage 0 MRONJ of the bilateral mandible, refractory to clindamycin and local debridement, who was subsequently managed successfully with amoxicillin/clavulanate and HBO2 therapy. The authors also explore the current literature on the pathophysiology of MRONJ and the potential role of hyperbaric oxygen in its treatment.

Address: Medical Student, NYU School of Medicine, New York, New York U.S.; Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, New York U.S.; Department of Surgery, NYU Langone Health, New York, New York U.S.; Department of Oral and Maxillofacial Surgery, NYU College of Dentistry, New York, New York .U.S.; Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, New York U.S.

DOI: 10.22462/04.06.2020.10

MeSH Terms: Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Bisphosphonate-Associated Osteonecrosis of the Jaw, Combined Modality Therapy, Female, Humans, Hyperbaric Oxygenation, Middle Aged, Osteoporosis