What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?

Address: Department of Neurology, Neurocritical Care, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. [email protected].; Department of Neurosurgery, University of Cincinnati (UC) College of Medicine, Cincinnati, OH, USA.; Collaborative for Research on Acute Neurologic Injury, University of Cincinnati (UC) College of Medicine, Cincinnati, OH, USA.; UC Gardner Neuroscience Institute, Cincinnati, OH, USA.; Department of Neurology, Neurocritical Care, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Department of Anesthesiology and Intensive Care Medicine, Hospices Civils de Lyon, Hôpital Pierre Wertheimer, Lyon, France.; Lyon Neuroscience Research Centre, Lyon, France.; Centre Lyonnais d'Enseignement par la Simulation en Santé, SAMSEI, Université Claude Bernard Lyon 1, Lyon, France.; Department of Basic and Clinical Neuroscience, King's College, London, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.; Department of Neurology and Rehabilitation Medicine, University of Cincinnati (UC) College of Medicine, Cincinnati, OH, USA.; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Neurovascular Research Laboratory, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medical Informatics, University of Szeged, Szeged, H-6720, Hungary.; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Berlin, Germany.; Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark.; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.; Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.