Efficacy of chalcone and xanthine derivatives on lipase inhibition: A systematic review.

Dao Ngoc Hien Tam, Esraa Mahmoud Mostafa, Vo Linh Tu, Asmaa Ibrahim Rashidy, Evangelia Matenoglou, Mahmoud Kassem, Dang Thi Soa, Amera Bayumi, Hagar Ehab Said Emam, Linh Tran, Truong Van Dat, Nguyen Tien Huy

Journal: Chemical biology & drug design 2021;95(2):205-214

PMID: 31571371

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Losing weight has significant impact on chronic disease management. Orlistat, a lipase inhibitor, has alternative effect for weight controlling. To find more candidates, we conducted a review of chalcone and xanthine derivatives regarding their anti-lipase activity. Eight databases were searched including PubMed, Scopus, Web of Science (ISI), Virtual Health Library (VHL), System for Information on Grey Literature in Europe (SIGLE), Global Health Library (GHL), EMBASE, and Google Scholar in August 2018. We found chalcone scaffold was more effective on lipase inhibition than xanthine scaffold. Among 19 investigated chalcones, only isoliquiritigenin and licuroside demonstrated an effect on preventing weight gain and increase in the total cholesterol and total triglycerides aside apart from their high activity on inhibiting lipase. Effect and type of inhibition of individual chalcones differed depending on their structure. In addition, very few studies investigated xanthine compounds and their activities were inconsistent. We suggest more studies investigate the ability of chalcones and modifying their structure to find out other compounds with higher efficacy.

Address: Asia Shine Trading & Services Co., LTD, Ho Chi Minh City, Vietnam.; Online Research Club (http://onlineresearchclub.org), Nagasaki, Japan.; Faculty of Medicine, Port Said University, Port Said, Egypt.; University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.; Faculty of Medicine, Aswan University, Aswan, Egypt.; Aristotle University of Thessaloniki, Thessaloniki, Greece.; The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Vinh Medical University (VMU), Nghe An, Vietnam.; Faculty of Medicine, Ain Shams University, Cairo, Egypt.; Faculty of Science, Biotechnology and Biomolecular Chemistry Program, Cairo University, Giza, Egypt.; Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.; Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

DOI: 10.1111/cbdd.13626

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Chalcone, Enzyme Inhibitors, Lipase, Xanthine