Therapeutic potentials of curcumin in the treatment of glioblstoma.

Zahra Shabaninejad, Mohammad Hossein Pourhanifeh, Ahmad Movahedpour, Reza Mottaghi, Ali Nickdasti, Erfan Mortezapour, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Mohammad Sadeghian, Seyed Mojtaba Mousavi, Hamed Mirzaei

Journal: European journal of medicinal chemistry 2020;188():112040

PMID: 31927312

Full Text on Elsevier Science View on PubMed

Abstract

Glioblastoma multiforme (GBM), a greatly aggressive malignancy of the brain, is correlated with a poor prognosis and low rate of survival. Up to now, chemotherapy and radiation therapy after surgical approaches have been the treatments increasing the survival rates. The low efficacy of mentioned therapies as well as their side-effects has forced researchers to explore an appropriate alternative or complementary treatment for glioblastoma. In experimental models, it has been shown that curcumin has therapeutic potentials to fight against GBM. Given that curcumin has pharmacological effects against cancer stem cells, as major causes of resistance to therapy in glioblastoma cells. Moreover, it has been showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways. Curcumin would possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as therapeutic agent in the treatment of GBM.

Address: Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Halal Research Center of IRI, FDA, Tehran, Iran.; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Oral and Maxillofacial Surgery, Kashan University of Medical Sciences, Kashan, Iran.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R, Iran.; Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada.; Orthopedic Surgeon Fellowship of Spine Surgery, Sasan General Hospital, Tehran, Iran.; Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].

DOI: 10.1016/j.ejmech.2020.112040

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MeSH Terms: Antineoplastic Agents, Cell Proliferation, Curcumin, Drug Screening Assays, Antitumor, Glioblastoma, Humans, Lipids, Molecular Structure, Nanoparticles