Malignant Hyperthermia Update.

Herodotos Ellinas, Meredith A Albrecht

Journal: Anesthesiology clinics 2020;38(1):165-181

PMID: 32008650

Full Text on Elsevier Science View on PubMed

Abstract

Malignant hyperthermia (MH) is a rare but potentially lethal skeletal muscle disorder affecting calcium release channels. It is inherited in a mendelian autosomal dominant pattern with variable penetration. The initial clinical manifestations are of a hypermetabolic state with increased CO2 production, respiratory acidosis, increased temperature, and increased oxygen demands. If diagnosed late, MH progresses to multi-organ system failure and death. Current data suggest that mortality has improved to less than 5%. The gold standard for ruling out MH is the contracture test. Genetic testing is also available. MH-susceptible individuals should be clearly identified for safe administration of future anesthetics.

Address: Department of Anesthesiology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address: [email protected].; Department of Anesthesiology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.

DOI: 10.1016/j.anclin.2019.10.010

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MeSH Terms: Anesthesia, Humans, Malignant Hyperthermia