Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations.

Martin Krššák, Lucas Lindeboom, Vera Schrauwen-Hinderling, Lidia S Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Jürgen Machann, Roland Kreis, Chris Boesch

Journal: NMR in biomedicine 2022;34(5):e4266

PMID: 32022964

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Abstract

H-MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of H-MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.

Address: Division of Endocrinology and Metabolism, Department of Internal Medicine III & High Field MR Centre, Department of Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, Austria.; Department of Radiology and Nuclear Medicine and Department of Nutrition and Movement Science, Maastricht University Medical Center, Maastricht, The Netherlands.; Biomedical Research Consulting in Magnetic Resonance Spectroscopy, Albuquerque, New Mexico.; Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.; Department of Diagnostics and Therapeutics, University of Helsinki, Helsinki, Finland.; PeakAnalysts, Benenden, Kent, UK.; Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.; Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany.; Departments of Radiology and Biomedical Research, University and Inselspital, Bern, Switzerland.

DOI: 10.1002/nbm.4266

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https://doi.org/10.1002/nbm.4266

MeSH Terms: Consensus, Expert Testimony, Humans, Metabolic Networks and Pathways, Metabolome, Muscle, Skeletal, Proton Magnetic Resonance Spectroscopy