The cell biology of MHC class I antigen presentation.

A Williams, C A Peh, T Elliott

Journal: Tissue antigens 2002;59(1):3-17

PMID: 11972873

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

MHC class I antigen presentation refers to the co-ordinated activities of many intracellular pathways that promote the cell surface appearance of MHC class I/beta2m heterodimers loaded with a spectrum of self or foreign peptides. These MHC class I peptide complexes form ligands for CD8 positive T cells and NK cells. MHC class I heterodimers are loaded within the endoplasmic reticulum (ER) with peptides derived from intracellular proteins. Alternatively, MHC class I molecules may be loaded with peptides derived from extracellular proteins in a process called MHC class I cross presentation. This pathway is less well defined but can overlap those pathways operating in classical MHC class I presentation and has recently been reviewed elsewhere (1). This review will address the current concepts regarding the intracellular assembly of MHC class I molecules with their peptide cargo within the ER and their subsequent progress to the cell surface.

Address: Cancer Sciences Division, University of Southampton School of Medicine, UK.

DOI: 10.1034/j.1399-0039.2002.590103.x

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/CPTAC-421

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-C-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Antigen Presentation, Antiporters, Biological Transport, Calcium-Binding Proteins, Calnexin, Calreticulin, Heat-Shock Proteins, Histocompatibility Antigens Class I, Humans, Immunoglobulins, Isomerases, Membrane Transport Proteins, Models, Immunological, Molecular Chaperones, Protein Disulfide-Isomerases, Protein Structure, Tertiary, Receptors, Cell Surface, Ribonucleoproteins