Molecular epidemiology and evolution of Haemophilus influenzae.

Shuxian Wen, Donghua Feng, Dingqiang Chen, Ling Yang, Zhenbo Xu

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2021;80():104205

PMID: 31981610

Full Text on Elsevier Science View on PubMed

Abstract

Haemophilus influenzae remains a common cause of illness in children worldwide. H. influenzae type b is the leading cause of bacterial meningitis in children before introduction of vaccination and is a common cause of pneumonia, epiglottis and septic arthritis. Since the implementation of the Hib conjugate vaccine, the non-typeable H. influenzae has rapidly decreased in respiratory and invasive infections in children and adults. However, the rate of antibiotic resistance of H. influenzae varies with region and period and is usually on the rise. In this review, typing of H. influenzae, virulence factors and resistance will be dissertated.

Address: Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: [email protected].; School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Department of Microbial Pathogenesis, University of Maryland, Baltimore 21201, USA; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address: [email protected].

DOI: 10.1016/j.meegid.2020.104205

Link outs

Free resources

Medical:

https://medlineplus.gov/haemophilusinfections.html

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1567...

MeSH Terms: Anti-Bacterial Agents, Biofilms, Drug Resistance, Bacterial, Evolution, Molecular, Haemophilus Infections, Haemophilus influenzae, Haemophilus influenzae type b, Humans, Molecular Epidemiology, Polysaccharides, Bacterial, Serotyping, Virulence, Virulence Factors, beta-Lactam Resistance