Onno W Akkerman, Lies Ter Beek, Rosella Centis, Markus Maeurer, Dina Visca, Marcela Muñoz-Torrico, Simon Tiberi, Giovanni Battista Migliori
Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2020;92S():S10-S14
PMID: 31982628
BACKGROUND
The holistic management of tuberculosis (TB) patients can improve life expectancy and lost organ function.
REHABILITATION
Chronic sequelae are very common among patients who survive TB, which can lead to a further decline in lung function. There is still no guidance for 'cured' patients with impaired lung function who need pulmonary rehabilitation. Additional tests for evaluation should be given after the end of treatment, as recent studies have shown the good effect of pulmonary rehabilitation for TB patients.
OPTIMIZED NUTRITIONAL CARE
Malnutrition is very common among TB patients and is related to malabsorption. The latter can cause lower drug exposure, which may result in treatment failure, increasing the risk of death, and can lead to acquired drug resistance. Malnutrition should be assessed according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and the diagnosis should lead to an individualized treatment plan, including sufficient proteins and preferably in combination with adequate training.
PROTECTIVE IMMUNE RESPONSES
Under normal circumstances, most immune cells use a glucose-based mechanism to generate energy. Therefore the patient's nutritional status is a key factor in shaping immune responses. Disease-related malnutrition leads to proteolysis and lipolysis. In the end, the identification of individuals who will benefit from immune-modulatory strategies may lead to clinically relevant markers.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Full Text Sources:
Medical:
Full Text Sources:
© Copyright 2026, Nutrition Evidence
We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.