Nuclear export: DNA-binding domains find a surprising partner.

D B DeFranco

Journal: Current biology : CB 2002;11(24):R1036-7

PMID: 11747843

Free Full Text on Elsevier Science View on PubMed

Abstract

Calreticulin, a calcium-binding protein of the endoplasmic reticulum, has been found to function as a nuclear export factor for a large family of nuclear receptors. Atypical nuclear export pathways may thus exist that regulate the compartmentalization and activity of a distinct set of transcription factors.

Address: Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. [email protected]

DOI: 10.1016/s0960-9822(01)00619-4

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https://linkinghub.elsevier.com/retrieve/pii/S0960...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CALR-1

MeSH Terms: Calcium-Binding Proteins, Calreticulin, Cell Nucleus, DNA-Binding Proteins, Protein Transport, Ribonucleoproteins