Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.

Sharanya Sivanand, Matthew G Vander Heiden

Journal: Cancer cell 2020;37(2):147-156

PMID: 32049045

Free Full Text on Elsevier Science View on PubMed

Abstract

Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.

Address: Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: [email protected].

DOI: 10.1016/j.ccell.2019.12.011

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https://medlineplus.gov/cancer.html

MeSH Terms: Amino Acids, Branched-Chain, Epigenomics, Humans, Intracellular Signaling Peptides and Proteins, Isoleucine, Leucine, Neoplasms