Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.

Paul D Kruithof, Sergey Lunev, Sheila P Aguilar Lozano, Fernando de Assis Batista, Zayana M Al-Dahmani, Jaap A Joles, Amalia M Dolga, Matthew R Groves, Harry van Goor

Journal: Biochimica et biophysica acta. Molecular basis of disease 2020;1866(6):165716

PMID: 32061776

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Abstract

Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

Address: Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.; University Medical Center Utrecht, Department of Nephrology and Hypertension, the Netherlands.; University of Groningen, Department of Pharmacy, Molecular Pharmacology, the Netherlands.; University Medical Center Groningen, Department of Pathology and Medical Biology the Netherlands. Electronic address: [email protected].

DOI: 10.1016/j.bbadis.2020.165716

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0925...

Medical:

https://medlineplus.gov/metabolicdisorders.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3884

Molecular Biology Databases:

https://glygen.org/publication/PubMed/32061776/

MeSH Terms: Antioxidants, Glutathione, Humans, Iron-Sulfur Proteins, Metabolic Diseases, Selenium, Sulfur, Thioredoxins, Thiosulfate Sulfurtransferase