Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases.

Dong Wang, Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G Nebigil, Laurent Désaubry

Journal: Cellular and molecular life sciences : CMLS 2020;77(18):3525-3546

PMID: 32062751

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Abstract

Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.

Address: Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.; Laboratory of Cardio-Oncology and Medicinal Chemistry (FRE 2033), CNRS, Institut Le Bel, 4 rue Blaise Pascal, CS 90032, 67081, Strasbourg, France.; Superior National School Biotechnology Taoufik Khaznadar, Ville universitaire Ali Mendjeli, BP E66 25100, Constantine, Algeria.; Cell Biology Unit, University Medical Center Mainz, JGU-Mainz, Mainz, Germany.; Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China. [email protected].; Laboratory of Cardio-Oncology and Medicinal Chemistry (FRE 2033), CNRS, Institut Le Bel, 4 rue Blaise Pascal, CS 90032, 67081, Strasbourg, France. [email protected].

DOI: 10.1007/s00018-020-03475-1

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MeSH Terms: Gene Expression, Heart Diseases, Humans, Ligands, Neoplasms, Nervous System Diseases, Osteoporosis, Prohibitins, Protein Processing, Post-Translational, Repressor Proteins, Signal Transduction