The genetics and epigenetics of orofacial clefts.

R A Spritz

Journal: Current opinion in pediatrics 2002;13(6):556-60

PMID: 11753106

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Abstract

Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects, but very little is known about their causation. Genetic factors are thought to play a major role, and there has been considerable recent effort to map and identify genes that constitute risk factors for clefts. This review will put into perspective the frequently-conflicting results of these studies.

Address: Department of Pediatrics and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, USA.

DOI: 10.1097/00008480-200112000-00011

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MeSH Terms: Cleft Lip, Cleft Palate, Folic Acid, Genetic Linkage, Homeodomain Proteins, Humans, MSX1 Transcription Factor, Mutation, Syndrome, T-Box Domain Proteins, Transcription Factors