Intravenous Lipid Emulsions in the NICU.

Kara L Calkins, Daniel T Robinson

Journal: NeoReviews 2021;21(2):e109-e119

PMID: 32005721

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Abstract

The clinical goals of intravenous lipid emulsions (ILEs) have changed since their initial development. In the past, 100% soybean oil was used to provide energy and prevent an essential fatty acid deficiency. Now, different oil sources are used with the goal of improving nutritional status and preventing common neonatal comorbidities. We now have a better understanding of specific ILE constituents, namely, fatty acids, vitamin E, and phytosterols, and how these components contribute to complications such as intestinal failure-associated liver disease. This review addresses the development and composition of different ILEs and summarizes how individual ILE ingredients affect infant metabolism and health.

Address: Department of Pediatrics, Division of Neonatology & Developmental Biology, Neonatal Research Center of the UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.; Department of Pediatrics, Northwestern University Feinberg School of Medicine and Division of Neonatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.

DOI: 10.1542/neo.21-2-e109

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MeSH Terms: Fat Emulsions, Intravenous, History, 20th Century, History, 21st Century, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Intensive Care, Neonatal