Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: A randomized controlled trial.

Leila Nazari, Saghar Salehpour, Sedigheh Hosseini, Nasrin Saharkhiz, Elham Azizi, Teibeh Hashemi, Robabeh Ghodssi-Ghassemabadi

Journal: Journal of gynecology obstetrics and human reproduction 2021;49(5):101698

PMID: 32018040

Full Text on Elsevier Science View on PubMed

Abstract

PURPOSE

This study has evaluated the use of myo-inositol supplementation for improving reproductive outcomes in poor responders undergoing intracytoplasmic sperm injection (ICSI).

METHODS

One hundred and twelve poor responder patients were included in the study and randomly categorized into two groups using a permuted block randomization method. Group A included 56 patients who received myo-inositol (4 g) and folic acid (400 μg) daily from one month before starting the ICSI cycle continuing until the ovulation triggering day. Group B included 56 patients consuming only folic acid (400 μg) daily for the same period. The outcome measures were the number of retrieved oocytes, embryo quality, Ovarian Sensitivity Index (OSI: number of oocytes retrieved/total Gonadotropins units × 1000), fertilization, implantation, and ongoing pregnancy rates.

RESULTS

No significant difference was observed between the two groups regarding the total dose of gonadotropin used, OSI, and the number of total retrieved and mature oocytes. Grad A embryos and fertilization rate were significantly increased in group A. Implantation and pregnancy rates showed statistically insignificant changes.

CONCLUSION

Treatment of poor responders with myo-inositol from one month before starting ICSI cycle continuing until ovulation trigger can improve fertilization rate and embryo quality, and may enhance the cumulative pregnancy rate in poor responders.

Address: Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; IVF Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biology and Anatomical Sciences, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; IVF Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

DOI: 10.1016/j.jogoh.2020.101698

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MeSH Terms: Adult, Dietary Supplements, Drug Combinations, Embryo Implantation, Female, Folic Acid, Follicle Stimulating Hormone, Humans, Infertility, Female, Inositol, Luteinizing Hormone, Middle Aged, Oocyte Retrieval, Ovulation Induction, Pregnancy, Pregnancy Rate, Sperm Injections, Intracytoplasmic, Treatment Outcome