Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues.

Danielly C Ferraz da Costa, Luciana Pereira Rangel, Mafalda Maria Duarte da Cunha Martins-Dinis, Giulia Diniz da Silva Ferretti, Vitor F Ferreira, Jerson L Silva

Journal: Molecules (Basel, Switzerland) 2020;25(4):893

PMID: 32085381

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Abstract

This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug candidates for cancer. A brief history of these compounds is reviewed along with their potential effects and mechanisms of action and the most recent attempts to improve their bioavailability and potency against different types of cancer.

Address: Departamento de Nutrição Básica e Experimental, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-013, Brazil.; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.; Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.; Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rio de Janeiro 24241-000, Brazil.

DOI: 10.3390/molecules25040893

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MeSH Terms: Antineoplastic Agents, Humans, Inhibitory Concentration 50, Naphthoquinones, Neoplasms, Resveratrol, Tumor Suppressor Protein p53