Metabolic regulation of calcium signaling in beta cells.

Olof Idevall-Hagren, Anders Tengholm

Journal: Seminars in cell & developmental biology 2021;103():20-30

PMID: 32085965

Free Full Text on Elsevier Science View on PubMed

Abstract

The cytoplasmic Ca concentration ([Ca]) regulates a vast number of cellular functions, including insulin secretion from beta cells. The major physiological insulin secretagogue, glucose, triggers [Ca] oscillations in beta cells. Synchronization of the oscillations among the beta cells within an islet underlies the generation of pulsatile insulin secretion. This review describes the mechanisms generating [Ca] oscillations, the interactions between [Ca] and cell metabolism, as well as the contribution of various organelles to the shaping of [Ca] signals and insulin secretion. It also discusses how Ca signals are coordinated and spread throughout the islets and data indicating that altered Ca signaling is associated with beta cell dysfunction and development of type 2 diabetes.

Address: Department of Medical Cell Biology, Uppsala University, Biomedical Centre, Box 571, SE-751 23 Uppsala, Sweden.; Department of Medical Cell Biology, Uppsala University, Biomedical Centre, Box 571, SE-751 23 Uppsala, Sweden. Electronic address: [email protected].

DOI: 10.1016/j.semcdb.2020.01.008

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1084...

Medical:

https://medlineplus.gov/diabetestype2.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-177

MeSH Terms: Calcium Signaling, Diabetes Mellitus, Type 2, Humans, Insulin-Secreting Cells