From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme.

Samantha A Swenson, Courtney M Moore, Jason R Marcero, Amy E Medlock, Amit R Reddi, Oleh Khalimonchuk

Journal: Cells 2021;9(3):579

PMID: 32121449

Abstract

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.

Address: Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Augusta University/University of Georgia Medical Partnership, Athens, GA 30602, USA.; Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA.; Fred and Pamela Buffett Cancer Center, Omaha, NE 68105, USA.

DOI: 10.3390/cells9030579

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https://bio-protocol.org/e1594

MeSH Terms: Heme, Mitochondria