Laryngopharyngeal Reflux and Atypical Gastroesophageal Reflux Disease.

Caroline M Barrett, Dhyanesh Patel, Michael F Vaezi

Journal: Gastrointestinal endoscopy clinics of North America 2020;30(2):361-376

PMID: 32146951

Full Text on Elsevier Science View on PubMed

Abstract

Laryngopharyngeal reflux and atypical manifestations of gastroesophageal reflux disease have a high economic and social burden in the United States. There is increasing research supporting the reflex theory and hypersensitivity syndrome underlying this disease pathophysiology. Novel diagnostic biomarkers have gained more traction in the search for a more reliable diagnostic tool, but further research is needed. Current standard-of-care treatment relies on proton pump inhibitor therapy. Antireflux surgery is usually not recommended. Neuromodulators and treatments targeting specific neuronal receptors are discussed. A diagnostic algorithm is proposed for the evaluation of laryngeal symptoms suspected to be related to extraesophageal reflux disease.

Address: Department of Internal Medicine, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20400, Nashville, TN 37204, USA.; Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, 1301 Medical Center Drive, TVC # 1660, Nashville, TN 37232, USA. Electronic address: [email protected].; Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, 1301 Medical Center Drive, TVC # 1660, Nashville, TN 37232, USA.

DOI: 10.1016/j.giec.2019.12.004

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MeSH Terms: Algorithms, Decision Support Systems, Clinical, Diagnosis, Differential, Gastroesophageal Reflux, Humans, Laryngopharyngeal Reflux, Larynx, Neurotransmitter Agents, Proton Pump Inhibitors