Annexin A1 involved in the regulation of inflammation and cell signaling pathways.

Peng-Fei Han, Xian-Da Che, Hong-Zhuo Li, Yang-Yang Gao, Xiao-Chun Wei, Peng-Cui Li

Journal: Chinese journal of traumatology = Zhonghua chuang shang za zhi 2020;23(2):96-101

PMID: 32201231

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Abstract

With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper.

Address: Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China.; Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China.; Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China. Electronic address: [email protected].

DOI: 10.1016/j.cjtee.2020.02.002

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https://assays.cancer.gov/CPTAC-311

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-ANXA1-1

MeSH Terms: Annexin A1, Apoptosis, Calcium, Cell Proliferation, Humans, Inflammation, Phospholipids, Protein Binding, Proteomics, Signal Transduction