Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.

Leila Shirmohammadi, Majid Ghayour-Mobarhan, Maryam Saberi-Karimian, Mehrdad Iranshahi, Shima Tavallaie, Marzieh Emamian, Amirhossein Sahebkar

Journal: Cardiovascular & hematological disorders drug targets 2021;20(2):116-121

PMID: 31538907

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Abstract

BACKGROUND

Inflammation has been shown to accompany Metabolic Syndrome (MetS) and its features. Cathepsin D is one of a proinflammatory mediator. In the current study, we aimed to investigate the effect of curcumin supplementation on serum cathepsin D levels in patients with MetS.

METHODS

The current study was conducted on 18-65 years old individuals with MetS diagnosed according to the International Diabetes Federation guidelines. A total of 80 participants were randomly divided into treatment and control groups. The first group (n=40) was given 2 capsules containing 500 mg of phosphatidylcholine complex of curcumin, and the other group (n=40) was given two 500 mg placebo capsules for 6 weeks. Before (week 0) and after (week 6) the intervention, anthropometric indices and blood pressure were measured and blood samples were taken. Serum cathepsin D was measured using an ELISA kit.

RESULTS

There was no significant difference between treatment and control groups in terms of weight, body mass index, waist circumference and serum cathepsin D levels before and after the intervention. In addition, there was no significant difference between pre- and post-trial values of serum cathepsin D.

CONCLUSION

The present results do not suggest any effect of curcumin on cathepsin D levels in patients with MetS.

Address: School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Student Research Committee, Iranian UNESCO Center of Excellence for Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Halal Research Center of IRI, FDA, Tehran, Iran.; Department of Biotechnology, School of Medicine, Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1871529X19666190919110652

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MeSH Terms: Adolescent, Adult, Aged, Cathepsin D, Curcumin, Female, Humans, Male, Metabolic Syndrome, Middle Aged, Young Adult