Citrus species: A Review of Traditional Uses, Phytochemistry and Pharmacology.

Elaheh Zibaee, Safa Kamalian, Mehrangiz Tajvar, Mohammad S Amiri, Mahin Ramezani, Ali T Moghadam, Seyed A Emami, Amirhossein Sahebkar

Journal: Current pharmaceutical design 2020;26(1):44-97

PMID: 31775593

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Abstract

The Citrus species from family Rutaceae has worldwide applications such as cardiovascular and gastrointestinal problems. Phytochemical investigations have shown that these plants have constituents including flavonoids, limonoids and carotenoids. There are many reports on a wide range of activities such as antiinflammatory, anti-oxidant, immunomodulatory, metabolic, cardiovascular and neuroprotective effects. In the current review, we discuss information regarding botany, phytochemistry, ethnobotany uses, traditional knowledge and pharmacological aspects of the Citrus species.

Address: Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Biology, Payame Noor University, Tehran, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Halal Research Center of IRI, FDA, Tehran, Iran.; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1381612825666191127115601

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MeSH Terms: Citrus, Ethnobotany, Ethnopharmacology, Phytochemicals, Phytotherapy, Plant Extracts